Endocrine Abstracts

Case: A 42-year old woman was referred to the endocrinology department for polydipsia and polyuria of sudden onset one month prior to presentation. She drank between 8 and 10 litres of water per day and complained of thirst, asthenia and lighter menstruation under her usual oral contraceptive pill. In addition to contraception she took 50 μg of L-thyroxine for Hashimoto thyroïditis. She had also a medical history of pink-red cutaneous lesions evolving for more than 1...

Context: Recombinant human GH (rhGH) is indicated for the treatment of adult subjects with GH deficiency (GHD). However, conflicting data are available on the efficacy of rhGH treatment in elderly GHD patients.Objective: To assess the efficacy of rhGH treatment in elderly GHD subjects.Methods: We searched PubMed, Cochrane Library, Web of Science, and EMBASE.Study selection: Eligible studies included GHD patie...

Background: According to western literature aerobic Gram-positive cocci are the predominant microorganisms that are isolated from diabetic foot ulcers. In contrast, whatever limited data is available from India Gram-negative aerobic bacteria were most frequently isolated.Aims and objectives: To know the clinical and microbiological profile of patients with infected diabetic foot ulcers.Patients and methods: A descriptive cross-sect...

Objective: Polycystic ovary syndrome (PCOS) is a common endocrine disorder, characterized by hyperandrogenism and chronic anovulation. Hyperinsulinemia and insulin resistance are well-documented features of the disease. In obese PCOS patients, family history of type 2 diabetes mellitus (FH-DM) is shown to be related with a decrease in insulin sensitivity, however not much is known about lean PCOS cases. The aim of this study was to determine the relationship between FH-DM and ...

Polycystic ovary syndrome (PCOS) is a common endocrinopathy with hyperandrogenemia to be its strongest genetically determined characteristic. Our aim was to investigate the potential synergy of two functional polymorphisms: the (TAAAA)n polymorphism of the sex hormone-binding globulin gene (SHBG) known to be associated with PCOS and influence serum SHBG levels (longer repeats were associated with lower SHBG levels) and the (CAG)n polymorphism of androgen receptor gene (...

Background: The study of the state of the pituitary-gonadal axis (PGA) in users of anabolic androgenic steroids (AAS) is important. The severity of inhibition of luteinizing (LH), follicle-stimulating (FSH) hormones, total testosterone (Tt), inhibin B may depend on the type of AAS used, its doses, the simultaneous use of several types of AAS and the duration of their administration.Aim: To evaluate the levels of LH, FSH, Tt and Inhibin B depending on the...

BACKGROUND: Dopamine agonists are the treatment of choice in macroprolactinomas. A number of these tumours do not respond to the commonly used doses. In such cases the outcome after alternative approaches has not been clarified.AIM: To assess the response of macroprolactinomas to bromocriptine (BRC) or cabergoline (CAB) and the result of further interventions in resistant cases.PATIENTS AND METHODS: All records of the patients pres...

The prevalence of cardiovascular diseases (CVD) has increased sharply in the developing countries and because Type 2 diabetic patients are at increased risk for CVD.Objective: To determine the prevalence of patients with past hystory of a myocardial infarction or cerebral strok in newly diagnosed type 2 diabetic patients in Georgia.Design: Cross-sectional study.Patients: Newly diagnosed type 2 diabetic patien...

Introduction: Large prolactinomas are uncommon and there is limited information on their presentation and progression. In this study we reviewed the presenting features, associated endocrinopathy and the response to treatment.Methods: 16 patients (aged 20–80 years, 75% male) were identified from our endocrine database as presenting with prolactin >20,000 mU/l between 1985 and 2005.Results: 75% of patients presented with ma...

The aim: To reveal relation between altered left ventricular (LV) geometry (G) and contractile ability (CA) in nonbese type 2 diabetic (DM2) patients with mild hypertension (MH).Materials and methods: BP at rest, 24-h ambulatory BP monitoring and echocardiography were investigated in 70 non-obese males, aged 25–50 yrs. They were divided into the following groups: Gr.1, n=15 – DM2 and normal BP, fasting C-peptide (C-p, ng/ml) 4.3±0.9...